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CXCR4-Targeted PET Imaging of Central Nervous System B-Cell Lymphoma

Herhaus, Peter ; Lipkova, Jana ; Lammer, Felicitas ; Yakushev, Igor ; Vag, Tibor ; Slotta-Huspenina, Julia ; Habringer, Stefan ; Lapa, Constantin ; Pukrop, Tobias ; Hellwig, Dirk ; Wiestler, Benedikt ; Buck, Andreas K. ; Deckert, Martina ; Wester, Hans-Jürgen ; Bassermann, Florian ; Schwaiger, Markus ; Weber, Wolfgang ; Menze, Björn ; Keller, Ulrich



Abstract

C-X-C chemokine receptor 4 (CXCR4) is a transmembrane chemokine receptor involved in growth, survival, and dissemination of cancer, including aggressive B-cell lymphoma. MRI is the standard imaging technology for central nervous system (CNS) involvement of B-cell lymphoma and provides high sensitivity but moderate specificity. Therefore, novel molecular and functional imaging strategies are ...

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