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Secreted Factors from Adipose Tissue Reprogram Tumor Lipid Metabolism and Induce Motility by Modulating PPARα/ANGPTL4 and FAK

Blücher, Christina ; Iberl, Sabine ; Schwagarus, Nancy ; Müller, Silvana ; Liebisch, Gerhard ; Höring, Marcus ; Hidrobo, Maria Soledad ; Ecker, Josef ; Spindler, Nick ; Dietrich, Arne ; Burkhardt, Ralph ; Stadler, Sonja C.


Recent studies indicate that adipose tissue in obesity promotes breast cancer progression by secreting protumorigenic chemokines, growth factors, and fatty acids. However, the detailed mechanisms by which hypertrophic adipose tissue influences breast cancer cells are still not well understood. Here we show that co-culture with adipose tissue from high-fat diet induced obese C57BL/6 mice alters ...


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