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Rat donor lung quality deteriorates more after fast than slow brain death induction

Dor, Frank JMF ; van Zanden, Judith E. ; Rebolledo, Rolando A. ; Hoeksma, Dane ; Bubberman, Jeske M. ; Burgerhof, Johannes G. ; Breedijk, Annette ; Yard, Benito A. ; Erasmus, Michiel E. ; Leuvenink, Henri G. D. ; Hottenrott, Maximilia C.


Donor brain death (BD) is initiated by an increase in intracranial pressure (ICP), which subsequently damages the donor lung. In this study, we investigated whether the speed of ICP increase affects quality of donor lungs, in a rat model for fast versus slow BD induction. Rats were assigned to 3 groups: 1) control, 2) fast BD induction (ICP increase over 1 min) or 3) slow BD induction (ICP ...


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