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Photocontrol of Endogenous Glycine Receptors In Vivo

Gomila, Alexandre M. J. ; Rustler, Karin ; Maleeva, Galyna ; Nin-Hill, Alba ; Wutz, Daniel ; Bautista-Barrufet, Antoni ; Rovira, Xavier ; Bosch, Miquel ; Mukhametova, Elvira ; Petukhova, Elena ; Ponomareva, Daria ; Mukhamedyarov, Marat ; Peiretti, Franck ; Alfonso-Prieto, Mercedes ; Rovira, Carme ; König, Burkhard ; Bregestovski, Piotr ; Gorostiza, Pau



Abstract

Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission ...

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