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Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis

Jia, Jiaoyuan ; Che, Li ; Cigliano, Antonio ; Wang, Xue ; Peitta, Graziella ; Tao, Junyan ; Zhong, Sheng ; Ribback, Silvia ; Evert, Matthias ; Chen, Xin ; Calvisi, Diego F.



Abstract

Hepatocellular carcinoma (HCC) is a deadly form of liver malignancy with limited treatment options. Amplification and/or overexpression of c-MYC is one of the most frequent genetic events in human HCC. The mammalian target of Rapamycin Complex 1 (mTORC1) is a major functional axis regulating various aspects of cellular growth and metabolism. Recently, we demonstrated that mTORC1 is necessary for ...

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