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Estrogen Actions in Triple-Negative Breast Cancer

Treeck, Oliver ; Schüler-Toprak, Susanne ; Ortmann, Olaf


Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) alpha, but the expression of estrogen receptors ER beta and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC. Estrogen signaling in TNBC can also be activated and modulated by the constitutively active estrogen-related receptors (ERRs). In this review article, we discuss the role of ER ...


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