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A Human Periodontal Ligament Fibroblast Cell Line as a New Model to Study Periodontal Stress

Weider, Matthias ; Schröder, Agnes ; Docheva, Denitsa ; Rodrian, Gabriele ; Enderle, Isabel ; Seidel, Corinna Lesley ; Andreev, Darja ; Wegner, Michael ; Bozec, Aline ; Deschner, James ; Kirschneck, Christian ; Proff, Peter ; Gölz, Lina


The periodontal ligament (PDL) is exposed to different kinds of mechanical stresses such as bite force or orthodontic tooth movement. A simple and efficient model to study molecular responses to mechanical stress is the application of compressive force onto primary human periodontal ligament fibroblasts via glass disks. Yet, this model suffers from the need for primary cells from human donors ...


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