Uhl, Franziska M. ; Chen, Sophia 
; O’Sullivan, David ; Edwards-Hicks, Joy ; Richter, Gesa ; Haring, Eileen ; Andrieux, Geoffroy ; Halbach, Sebastian ; Apostolova, Petya ; Büscher, Jörg ; Duquesne, Sandra ; Melchinger, Wolfgang ; Sauer, Barbara ; Shoumariyeh, Khalid ; Schmitt-Graeff, Annette ; Kreutz, Marina ; Lübbert, Michael ; Duyster, Justus ; Brummer, Tilman ; Boerries, Melanie ; Madl, Tobias ; Blazar, Bruce R. ; Groß, Olaf ; Pearce, Erika L. ; Zeiser, Robert
; O’Sullivan, David ; Edwards-Hicks, Joy ; Richter, Gesa ; Haring, Eileen ; Andrieux, Geoffroy ; Halbach, Sebastian ; Apostolova, Petya ; Büscher, Jörg ; Duquesne, Sandra ; Melchinger, Wolfgang ; Sauer, Barbara ; Shoumariyeh, Khalid ; Schmitt-Graeff, Annette ; Kreutz, Marina ; Lübbert, Michael ; Duyster, Justus ; Brummer, Tilman ; Boerries, Melanie ; Madl, Tobias ; Blazar, Bruce R. ; Groß, Olaf ; Pearce, Erika L. ; Zeiser, Robert 
Abstract
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after allo-HCT exhibited reduced glycolysis and interferon-gamma production. Functional studies in multiple mouse models of leukemia showed that leukemia-derived lactic acid (LA) interfered with T cell glycolysis and ...
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