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Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial

van Dijk, Nick ; Gil-Jimenez, Alberto ; Silina, Karina ; Hendricksen, Kees ; Smit, Laura A. ; de Feijter, Jeantine M. ; van Montfoort, Maurits L. ; van Rooijen, Charlotte ; Peters, Dennis ; Broeks, Annegien ; van der Poel, Henk G. ; Bruining, Annemarie ; Lubeck, Yoni ; Sikorska, Karolina ; Boellaard, Thierry N. ; Kvistborg, Pia ; Vis, Daniel J. ; Hooijberg, Erik ; Schumacher, Ton N. ; van den Broek, Maries ; Wessels, Lodewyk F. A. ; Blank, Christian U. ; van Rhijn, Bas W. ; van der Heijden, Michiel S.



Abstract

Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown remarkable pathological responses in melanoma(1)and colorectal cancer(2). In NABUCCO (ClinicalTrials.gov:), a single-arm feasibility trial, 24 patients with stage III urothelial cancer (UC) received two doses of ipilimumab and two doses of nivolumab, followed by resection. The primary endpoint was feasibility to resect ...

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