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The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice

Rangrez, Ashraf Yusuf ; Borlepawar, Ankush ; Schmiedel, Nesrin ; Deshpande, Anushka ; Remes, Anca ; Kumari, Manju ; Bernt, Alexander ; Christen, Lynn ; Helbig, Andreas ; Jungmann, Andreas ; Sossalla, Samuel ; Tholey, Andreas ; Müller, Oliver J. ; Frank, Derk ; Frey, Norbert



Abstract

Myocardial inflammation has recently been recognized as a distinct feature of cardiac hypertrophy and heart failure. HectD3, a HECT domain containing E3 ubiquitin ligase has previously been investigated in the host defense against infections as well as neuroinflammation; its cardiac function however is still unknown. Here we show that HectD3 simultaneously attenuates Calcineurin-NFAT driven ...

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