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Reporting of Safety Events during Anti-VEGF Treatment: Pharmacovigilance in a Noninterventional Trial

Ziemssen, Focke ; Hammer, Thomas ; Grueb, Matthias ; Mueller, Bettina ; Berk, Hüsnü ; Gamulescu, Maria-Andreea ; Voegeler, Jessica ; Wachtlin, Joachim ; OCEAN Study Group, ; Rechichi, Miguel


Aim. The prospective, noninterventional OCEAN study assessed the safety of intravitreal ranibizumab injections for treatment of neovascular age-related macular degeneration, diabetic macular edema, and retinal vein occlusion under real-world conditions in Germany.Methods. Adults receiving >= 1 ranibizumab (0.5 mg) injections were recruited by 369 ophthalmologists and followed for 24 months. ...


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