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PSMA-Directed CAR T Cells Combined with Low-Dose Docetaxel Treatment Induce Tumor Regression in a Prostate Cancer Xenograft Model

Alzubi, Jamal ; Dettmer-Monaco, Viviane ; Kuehle, Johannes ; Thorausch, Niko ; Seidl, Maximilian ; Taromi, Sanaz ; Schamel, Wolfgang ; Zeiser, Robert ; Abken, Hinrich ; Cathomen, Toni ; Wolf, Philipp


While chimeric antigen receptor (CAR) T cell immunotherapy targeting CD19 has shown remarkable success in patients with lymphoid malignancies, the potency of CAR T cells in solid tumors is low so far. To improve the efficacy of CAR T cells targeting prostate carcinoma, we designed a novel CAR that recognizes a new epitope in the prostate-specific membrane antigen (PSMA) and established novel ...


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