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Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination

Wüst, Hannah M. ; Wegener, Amélie ; Fröb, Franziska ; Hartwig, Anna C. ; Wegwitz, Florian ; Kari, Vijayalakshmi ; Schimmel, Margit ; Tamm, Ernst R. ; Johnsen, Steven A. ; Wegner, Michael ; Sock, Elisabeth



Abstract

Schwann cells are the nerve ensheathing cells of the peripheral nervous system. Absence, loss and malfunction of Schwann cells or their myelin sheaths lead to peripheral neuropathies such as CharcotMarie-Tooth disease in humans. During Schwann cell development and myelination chromatin is dramatically modified. However, impact and functional relevance of these modifications are poorly understood. ...

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