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Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir

Patasic, Lea ; Seifried, Janna ; Bezler, Valerie ; Kaljanac, Marcell ; Schneider, Irene C. ; Schmitz, Heike ; Tondera, Christiane ; Hartmann, Jessica ; Hombach, Andreas ; Buchholz, Christian J. ; Abken, Hinrich ; König, Renate ; Cichutek, Klaus



Abstract

Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4(+)target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.


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