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Remote Control of Neural Stem Cell Fate Using NIR-Responsive Photoswitching Upconversion Nanoparticle Constructs

Zhang, Yixiao ; Wiesholler, Lisa M. ; Rabie, Hudifah ; Jiang, Pengfei ; Lai, Jinping ; Hirsch, Thomas ; Lee, Ki-Bum



Abstract

Light-mediated remote control of stem cell fate, such as proliferation, differentiation, and migration, can bring a significant impact on stem cell biology and regenerative medicine. Current UV/vis-mediated control approaches are limited in terms of nonspecific absorption, poor tissue penetration, and phototoxicity. Upconversion nanoparticle (UCNP)-based near-infrared (NIR)-mediated control ...

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