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The transitional phase of multiple sclerosis: Characterization and conceptual framework

Kleiter, Ingo ; Ayzenberg, Ilya ; Havla, Joachim ; Lukas, Carsten ; Penner, Iris-Katharina ; Stadelmann, Christine ; Linker, Ralf A


The conversion of relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) cannot be defined by a sharp threshold determined by event-based measures, but rather represents a gradual process. In consequence, there may exist a transitional phase between RRMS and clearly established SPMS. So far, transitional MS has been poorly characterized in terms of patient properties, ...


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