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Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism

Metzendorf, Christoph ; Wineberger, Katharina ; Rausch, Jenny ; Cigliano, Antonio ; Peters, Kristin ; Sun, Baodong ; Mennerich, Daniela ; Kietzmann, Thomas ; Calvisi, Diego F. ; Dombrowski, Frank ; Ribback, Silvia



Abstract

Clear cell foci (CCF) of the liver are considered to be pre-neoplastic lesions of hepatocellular adenomas and carcinomas. They are hallmarked by glycogen overload and activation of AKT (v-akt murine thymoma viral oncogene homolog)/mTOR (mammalian target of rapamycin)-signaling. Here, we report the transcriptome and proteome of CCF extracted from human liver biopsies by laser capture ...

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