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Rescue of Hepatic Phospholipid Remodeling Defect in iPLA2β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver

Chamulitrat, Walee ; Jansakun, Chutima ; Li, Huili ; Liebisch, Gerhard


Polymorphisms of group VIA calcium-independent phospholipase A2 (iPLA(2)beta or PLA2G6) are positively associated with adiposity, blood lipids, and Type-2 diabetes. The ubiquitously expressed iPLA(2)beta catalyzes the hydrolysis of phospholipids (PLs) to generate a fatty acid and a lysoPL. We studied the role of iPLA(2)beta on PL metabolism in non-alcoholic fatty liver disease (NAFLD). By using ...


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