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Radiation with concurrent radiosensitizing capecitabine tablets and single-dose mitomycin-C for muscle-invasive bladder cancer: A convenient alternative to 5-fluorouracil

Voskuilen, Charlotte S. ; van de Kamp, Maaike W. ; Schuring, Nannet ; Mertens, Laura S. ; Noordzij, Arjen ; Pos, Floris ; van Rhijn, Bas W.G. ; van der Heijden, Michiel S. ; Schaake, Eva E.


Background and purpose: Chemoradiation (CRT) with mitomycin-C (MMC) and 5-fluorouracil (5-FU) has been shown to be superior to radiation alone in patients with muscle-invasive bladder cancer (MIBC). MMC/capecitabine is an effective replacement for 5FU as a radiosensitizer in other malignancies but has not been studied in bladder cancer. We evaluated the outcomes of MIBC patients treated with ...


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