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Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: Evaluation of the surface properties and effect on their distribution

Apaolaza, P.S. ; Busch, M. ; Asin-Prieto, E. ; Peynshaert, K. ; Rathod, R. ; Remaut, K. ; Dünker, N. ; Göpferich, A.


Due to the unique anatomical structure of the eye, ocular drug delivery is a promising delivery route for the treatment of several ocular diseases, such as the ocular neovascularization that contributes to diabetic retinopathy. This disease is triggered by inflammation, retinal ischemia, and/or deposits of advanced-glycation end-products (AGEs), as well as increased levels of vascular endothelial ...


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