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Genetic determinants of the humoral immune response in MS

Gasperi, Christiane ; Andlauer, Till F.M. ; Keating, Ana ; Knier, Benjamin ; Klein, Ana ; Pernpeintner, Verena ; Lichtner, Peter ; Gold, Ralf ; Zipp, Frauke ; Then Bergh, Florian ; Stangel, Martin ; Tumani, Hayrettin ; Wildemann, Brigitte ; Wiendl, Heinz ; Bayas, Antonios ; Kümpfel, Tania ; Zettl, Uwe K. ; Linker, Ralf A. ; Ziemann, Ulf ; Knop, Matthias ; Warnke, Clemens ; Friese, Manuel A. ; Paul, Friedemann ; Tackenberg, Björn ; Berthele, Achim ; Hemmer, Bernhard


Objective In this observational study, we investigated the impact of genetic factors at the immunoglobulin heavy chain constant locus on chromosome 14 and the major histocompatibility complex region on intrathecal immunoglobulin G, A, and M levels as well as on B cells and plasmablasts in the CSF and blood of patients with multiple sclerosis (MS). Methods Using regression analyses, we tested ...


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