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Melanoma brain metastases – Interdisciplinary management recommendations 2020

Gutzmer, Ralf ; Vordermark, Dirk ; Hassel, Jessica C. ; Krex, Dietmar ; Wendl, Christina ; Schadendorf, Dirk ; Sickmann, Thomas ; Rieken, Stefan ; Pukrop, Tobias ; Höller, Christoph ; Eigentler, Thomas K. ; Meier, Friedegund


Melanoma brain metastases (MBM) are common and associated with a particularly poor prognosis; they directly cause death in 60-70% of melanoma patients. In the past, systemic treatments have shown response rates around 5%, whole brain radiation as standard of care has achieved a median overall survival of approximately three months. Recently, the combination of immune checkpoint inhibitors and ...


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