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Inadequate tissue mineralization promotes cancer cell attachment

Dague, Etienne ; Sariisik, Ediz ; Zistl, Domenik ; Docheva, Denitsa ; Schilling, Arndt F. ; Benoit, Martin ; Sudhop, Stefanie ; Clausen-Schaumann, Hauke



Abstract

Bone metastases are a frequent complication in prostate cancer, and several studies have shown that vitamin D deficiency promotes bone metastases. However, while many studies focus on vitamin D's role in cell metabolism, the effect of chronically low vitamin D levels on bone tissue, i.e. insufficient mineralization of the tissue, has largely been ignored. To investigate, whether poor tissue ...

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