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The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis

Winkler, Emma S. ; Shrihari, Swathi ; Hykes, Barry L. ; Handley, Scott A. ; Andhey, Prabhakar S. ; Huang, Yan-Jang S. ; Swain, Amanda ; Droit, Lindsay ; Chebrolu, Kranthi K. ; Mack, Matthias ; Vanlandingham, Dana L. ; Thackray, Larissa B. ; Cella, Marina ; Colonna, Marco ; Artyomov, Maxim N. ; Stappenbeck, Thaddeus S. ; Diamond, Michael S.



Abstract

Chikungunya virus (CHIKV), an emerging alphavirus, has infected millions of people. However, the factors modulating disease outcome remain poorly understood. Here, we show in germ-free mice or in oral antibiotic-treated conventionally housed mice with depleted intestinal microbiomes that greater CHIKV infection and spread occurs within 1 day of virus inoculation. Alteration of the microbiome ...

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