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Prevention of dsRNA‐induced interferon signaling by AGO1x is linked to breast cancer cell proliferation

Ghosh, Souvik ; Guimaraes, Joao C. ; Lanzafame, Manuela ; Schmidt, Alexander ; Syed, Afzal Pasha ; Dimitriades, Beatrice ; Börsch, Anastasiya ; Ghosh, Shreemoyee ; Mittal, Nitish ; Montavon, Thomas ; Correia, Ana Luisa ; Danner, Johannes ; Meister, Gunter ; Terracciano, Luigi M. ; Pfeffer, Sébastien ; Piscuoglio, Salvatore ; Zavolan, Mihaela



Abstract

Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein-level modulation. Here, we report that AGO1x, an evolutionarily conserved translational readthrough isoform of Argonaute 1, is generated in highly proliferative breast cancer ...

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