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Dose-dependent regulation of horizontal cell fate by Onecut family of transcription factors

Badea, Tudor C. ; Kreplova, Michaela ; Kuzelova, Andrea ; Antosova, Barbora ; Zilova, Lucie ; Jägle, Herbert ; Kozmik, Zbynek



Abstract

Genome duplication leads to an emergence of gene paralogs that are essentially free to undergo the process of neofunctionalization, subfunctionalization or degeneration (gene loss). Onecut1 (Oc1) and Onecut2 (Oc2) transcription factors, encoded by paralogous genes in mammals, are expressed in precursors of horizontal cells (HCs), retinal ganglion cells and cone photoreceptors. Previous studies ...

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