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Capillary Zone Electrophoresis-Top-Down Tandem Mass Spectrometry for In-Depth Characterization of Hemoglobin Proteoforms in Clinical and Veterinary Samples

Stolz, Alexander ; Hedeland, Ylva ; Salzer, Liesa ; Römer, Jennifer ; Heiene, Reidun ; Leclercq, Laurent ; Cottet, Hervé ; Bergquist, Jonas ; Neusüß, Christian



Abstract

Hemoglobin (Hb) constitutes an important protein in clinical diagnostics-both in humans and animals. Among the high number of sequence variants, some can cause severe diseases. Moreover, chemical modifications such as glycation and carbamylation serve as important biomarkers for conditions such as diabetes and kidney diseases. In clinical routine analysis of glycated Hb, sequence variants or ...

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