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ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung

Schuijs, Martijn J. ; Png, Shaun ; Richard, Arianne C. ; Tsyben, Anastasia ; Hamm, Gregory ; Stockis, Julie ; Garcia, Celine ; Pinaud, Silvain ; Nicholls, Ashley ; Ros, Xavier Romero ; Su, Jing ; Eldridge, Matthew D. ; Riedel, Angela ; Serrao, Eva M. ; Rodewald, Hans-Reimer ; Mack, Matthias ; Shields, Jacqueline D. ; Cohen, E. Suzanne ; McKenzie, Andrew N. J. ; Goodwin, Richard J. A. ; Brindle, Kevin M. ; Marioni, John C. ; Halim, Timotheus Y. F.


Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid cells (ILC2s) orchestrated suppression of natural killer (NK) cell-mediated innate antitumor immunity, leading to increased lung metastases and mortality. Using multiple models of lung metastasis, we show that ...


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