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Mechanistic insights into Lhr helicase function in DNA repair

Buckley, Ryan J. ; Kramm, Kevin ; Cooper, Christopher D. O. ; Grohmann, Dina ; Bolt, Edward L.



Abstract

The DNA helicase Large helicase-related (Lhr) is present throughout archaea, including in the Asgard and Nanoarchaea, and has homologues in bacteria and eukaryotes. It is thought to function in DNA repair but in a context that is not known. Our data show that archaeal Lhr preferentially targets DNA replication fork structures. In a genetic assay, expression of archaeal Lhr gave a phenotype ...

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