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Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome. A Randomized Controlled Trial in Sheep

Millar, Jonathan E. ; Bartnikowski, Nicole ; Passmore, Margaret R. ; Obonyo, Nchafatso G. ; Malfertheiner, Maximillian V. ; von Bahr, Viktor ; Redd, Meredith A. ; See Hoe, Louise ; Ki, Katrina K. ; Pedersen, Sanne ; Boyle, Andrew J. ; Baillie, J. Kenneth ; Shekar, Kiran ; Palpant, Nathan ; Suen, Jacky Y. ; Matthay, Michael A. ; McAuley, Daniel F. ; Fraser, John F.



Zusammenfassung

Rationale: Mesenchymal stromal cell (MSC) therapy is a promising intervention for acute respiratory distress syndrome (ARDS), although trials to date have not investigated its use alongside extracorporeal membrane oxygenation (ECMO). Recent preclinical studies have suggested that combining these interventions may attenuate the efficacy of ECMO. Objectives: To determine the safety and efficacy of ...

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