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Impaired Renal HCO3- Excretion in Cystic Fibrosis

Berg, Peder ; Svendsen, Samuel L. ; Sorensen, Mads V. ; Larsen, Casper K. ; Andersen, Jesper Frank ; Jensen-Fangel, Søren ; Jeppesen, Majbritt ; Schreiber, Rainer ; Cabrita, Ines ; Kunzelmann, Karl ; Leipziger, Jens


Background Patients with cystic fibrosis (CF) do not respond with increased urinary HCO3- excretion after stimulation with secretin and often present with metabolic alkalosis. Methods By combining RT-PCR, immunohistochemistry, isolated tubule perfusion, in vitro cell studies, and in vivo studies in different mouse models, we elucidated the mechanism of secretin-induced urinary HCO3- excretion. ...


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