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Reactive increase of cerebrospinal fluid white blood cell count after lumbar puncture: Fact or fiction?

Neumann, Bernhard ; Steinberg, Tim ; Lee, De-Hyung ; Kress, Johanna ; Kufner, Marco ; Schlachetzki, Felix ; Weinfurtner, Georg ; Linker, Ralf ; Angstwurm, Klemens


Lumbar puncture (LP) is commonly used in the diagnostic workup of neurological patients, often to exclude inflammatory diseases of the central nervous system. In clinical practice, an increase of white blood cell count (WBC) in the cerebrospinal fluid (CSF) after a LP is often assumed as reactive to the first puncture. Scientific evidence of this hypothesis, however, is lacking. Retrospective ...


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