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Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins

Alzahofi, Noura ; Welz, Tobias ; Robinson, Christopher L. ; Page, Emma L. ; Briggs, Deborah A. ; Stainthorp, Amy K. ; Reekes, James ; Elbe, David A. ; Straub, Felix ; Kallemeijn, Wouter W. ; Tate, Edward W. ; Goff, Philip S. ; Sviderskaya, Elena V. ; Cantero, Marta ; Montoliu, Lluis ; Nedelec, Francois ; Miles, Amanda K. ; Bailly, Maryse ; Kerkhoff, Eugen ; Hume, Alistair N.


Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered that the motor protein myosin-Va works with dynamic actin tracks to drive long-range organelle dispersion in opposition to microtubules. This suggests that in animals, as ...


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