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Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis

Danzer, Heike ; Glaesner, Joachim ; Baerenwaldt, Anne ; Reitinger, Carmen ; Lux, Anja ; Heger, Lukas ; Dudziak, Diana ; Harrer, Thomas ; Gessner, André ; Nimmerjahn, Falk



Abstract

Pathogen-specific antibody responses need to be tightly regulated to generate protective but limit self-reactive immune responses. While loss of humoral tolerance has been associated with microbial infections, the pathways involved in balancing protective versus autoreactive antibody responses in humans are incompletely understood. Studies in classical mouse model systems have provided evidence ...

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