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The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD

van den Brink, Marcel R. M. ; Cross, Justin R. ; Peled, Jonathan U. ; Sung, Anthony D. ; Xavier, Joao ; Devlin, Sean M. ; Ponce, Doris M. ; Perales, Miguel-Angel ; Holler, Ernst ; Pamer, Eric G. ; Taur, Ying ; Giralt, Sergio ; Politikos, Ioannis ; Cho, Christina ; Maloy, Molly ; Chao, Nelson ; Rizzieri, David A. ; Lew, Meagan V. ; Covington, Megan ; Bohannon, Lauren ; Bush, Amy ; Rao, Arka ; Ramos, Ruben J. ; Clurman, Annelie G. ; Brereton, Daniel G. ; Nichols, Katherine B. ; Slingerland, John B. ; Slingerland, Ann E. ; Armijo, Gabriel K. ; Docampo, Melissa D. ; Dai, Anqi ; Weber, Daniela ; Giardina, Paul A. ; Taylor, Bradford P. ; Pickard, Amanda J. ; Littmann, Eric R. ; Gomes, Antonio L. C. ; Schluter, Jonas ; Markey, Kate A.



Zusammenfassung

Studies of the relationship between the gastrointestinal microbiota and outcomes in allogeneic hematopoietic stem cell transplantation (allo-HCT) have thus far largely focused on early complications, predominantly infection and acute graft-versus-host disease (GVHD). We examined the potential relationship of the microbiome with chronic GVHD (cGVHD) by analyzing stool and plasma samples collected ...

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