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Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias

Sossalla, Samuel ; Maier, Lars S. ; Neef, Stefan ; Wagner, Stefan ; Rupprecht, Leopold ; Keyser, Andreas ; Dybkova, Nataliya ; Lebek, Simon ; Stehle, Thea ; Mustroph, Julian ; Pabel, Steffen



Abstract

Aims In atrial fibrillation (AF), an increased diastolic Ca2+ leak from the sarcoplasmic reticulum (SR) mediated by calcium/calmodulin-dependent-protein-kinaseIIdC (CaMKII) can serve as a substrate for arrhythmia induction and persistence. Dantrolene has been shown to stabilize the cardiac ryanodine-receptor. This study investigated the effects of dantrolene on arrhythmogenesis in human and mouse ...

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