



Item type: | Article | ||||
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Journal or Publication Title: | Journal of Cardiovascular Pharmacology | ||||
Publisher: | LIPPINCOTT WILLIAMS & WILKINS | ||||
Place of Publication: | PHILADELPHIA | ||||
Volume: | Publish Ah | ||||
Date: | 2020 | ||||
Institutions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin I | ||||
Identification Number: |
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Keywords: | DECOMPENSATED HEART-FAILURE; IMPROVES RENAL-FUNCTION; AMYOTROPHIC-LATERAL-SCLEROSIS; RIGHT-VENTRICULAR FUNCTION; CARDIAC TROPONIN-C; EXTRACORPOREAL MEMBRANE-OXYGENATION; GLOMERULAR-FILTRATION-RATE; CALCIUM SENSITIZING DRUG; CORONARY BLOOD-FLOW; ARTERY-BYPASS GRAFT; acute heart failure; advanced heart failure; hemodynamics; inodilator; inotrope; neurohormone; regulatory clinical trial | ||||
Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Yes | ||||
Item ID: | 49879 |
Abstract
Levosimendan was first approved for clinical use in 2000, when authorization was granted by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely decompensated chronic heart failure (HF). In the ensuing 20 years, this distinctive inodilator, which enhances cardiac contractility through calcium sensitization and promotes vasodilatation through the opening of ...

Abstract
Levosimendan was first approved for clinical use in 2000, when authorization was granted by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely decompensated chronic heart failure (HF). In the ensuing 20 years, this distinctive inodilator, which enhances cardiac contractility through calcium sensitization and promotes vasodilatation through the opening of adenosine triphosphate-dependent potassium channels on vascular smooth muscle cells, has been approved in more than 60 jurisdictions, including most of the countries of the European Union and Latin America. Areas of clinical application have expanded considerably and now include cardiogenic shock, takotsubo cardiomyopathy, advanced HF, right ventricular failure, pulmonary hypertension, cardiac surgery, critical care, and emergency medicine. Levosimendan is currently in active clinical evaluation in the United States. Levosimendan in IV formulation is being used as a research tool in the exploration of a wide range of cardiac and noncardiac disease states. A levosimendan oral form is at present under evaluation in the management of amyotrophic lateral sclerosis. To mark the 20 years since the advent of levosimendan in clinical use, 51 experts from 23 European countries (Austria, Belgium, Croatia, Cyprus, Czech Republic, Estonia, Finland, France, Germany, Greece, Hungary, Italy, the Netherlands, Norway, Poland, Portugal, Russia, Slovenia, Spain, Sweden, Switzerland, the United Kingdom, and Ukraine) contributed to this essay, which evaluates one of the relatively few drugs to have been successfully introduced into the acute HF arena in recent times and charts a possible development trajectory for the next 20 years.
Metadata last modified: 12 Jan 2022 11:13