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Harmonization and Standardization of Panel-Based Tumor Mutational Burden Measurement: Real-World Results and Recommendations of the Quality in Pathology Study

Stenzinger, Albrecht ; Endris, Volker ; Budczies, Jan ; Merkelbach-Bruse, Sabine ; Kazdal, Daniel ; Dietmaier, Wolfgang ; Pfarr, Nicole ; Siebolts, Udo ; Hummel, Michael ; Herold, Sylvia ; Andreas, Johanna ; Zoche, Martin ; Tögel, Lars ; Rempel, Eugen ; Maas, Jörg ; Merino, Diana ; Stewart, Mark ; Zaoui, Karim ; Schlesner, Matthias ; Glimm, Hanno ; Fröhling, Stefan ; Allen, Jeff ; Horst, David ; Baretton, Gustavo ; Wickenhauser, Claudia ; Tiemann, Markus ; Evert, Matthias ; Moch, Holger ; Kirchner, Thomas ; Büttner, Reinhard ; Schirmacher, Peter ; Jung, Andreas ; Haller, Florian ; Weichert, Wilko ; Dietel, Manfred



Abstract

Introduction: Tumor mutational burden (TMB) is a quan-titative assessment of the number of somatic mutations within a tumor genome. Immunotherapy benefit has been associated with TMB assessed by whole-exome sequencing (wesTMB) and gene panel sequencing (psTMB). The initiatives of Quality in Pathology (QuIP) and Friends of Cancer Research have jointly addressed the need for harmonization among TMB ...

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