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Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way

Niedermair, Tanja ; Schirner, Stephan ; Lasheras, Mar Guaza ; Straub, Rainer H. ; Grässel, Susanne



Abstract

Mice with an overall deletion of the sensory neuropeptide alpha-calcitonin gene-related peptide (alpha-CGRP) develop an age-dependent osteopenic bone phenotype. Underlying molecular mechanisms of how alpha CGRP affects bone cell metabolism are not well understood. This study aims to characterize differences in metabolic parameters of osteoblast-like cells (OB) and differentiated bone ...

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