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The Hippo Effector Transcriptional Coactivator with PDZ-Binding Motif Cooperates with Oncogenic β-Catenin to Induce Hepatoblastoma Development in Mice and Humans

Zhang, Shu ; Zhang, Jie ; Evert, Katja ; Li, Xiaolei ; Liu, Pin ; Kiss, Andras ; Schaff, Zsuzsa ; Ament, Cindy ; Zhang, Yi ; Serra, Monica ; Evert, Matthias ; Chen, Nianyong ; Xu, Feng ; Chen, Xin ; Tao, Junyan ; Calvisi, Diego F. ; Cigliano, Antonio



Abstract

Hepatoblastoma (HB) is the most common pediatric liver tumor. Though Wnt/beta-catenin and Hippo cascades are implicated in HB development, studies on crosstalk between beta-catenin and Hippo downstream effector transcriptional coactivator with PDZ-binding motif (TAZ) in HB are lacking. Expression levels of TAZ and beta-catenin in human HB specimens were assessed by immunohistochemistry. ...

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