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Mammalian Target of Rapamycin Complex 2 Signaling Is Required for Liver Regeneration in a Cholestatic Liver Injury Murine Model

Zhou, Yi ; Xu, Meng ; Liu, Pin ; Liang, Binyong ; Qian, Manning ; Wang, Haichuan ; Song, Xinhua ; Nyshadham, Pranavanand ; Che, Li ; Calvisi, Diego F. ; Li, Feng ; Lin, Shumei ; Chen, Xin



Abstract

Cholestatic liver injury may lead to a series of hepatobiliary syndromes, which can progress to cirrhosis and impaired liver regeneration, eventually resulting in liver-related death. Mammalian target of rapamycin complex 2 (mTORC2) is a major regulator of liver metabolism and tumor development. However, the role of mTORC2 signaling in cholestatic liver injury has not been characterized to date. ...

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