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An epidemic CC1-MRSA-IV clone yields false-negative test results in molecular MRSA identification assays: a note of caution, Austria, Germany, Ireland, 2020

Monecke, Stefan ; König, Elisabeth ; Earls, Megan R. ; Leitner, Eva ; Müller, Elke ; Wagner, Gabriel E. ; Poitz, David M. ; Jatzwauk, Lutz ; Vremerǎ, Teodora ; Dorneanu, Olivia S. ; Simbeck, Alexandra ; Ambrosch, Andreas ; Zollner-Schwetz, Ines ; Krause, Robert ; Ruppitsch, Werner ; Schneider-Brachert, Wulf ; Coleman, David C. ; Steinmetz, Ivo ; Ehricht, Ralf



Zusammenfassung

We investigated why a clinical meticillin-resistant Staphylococcus aureus (MRSA) isolate yielded false-negative results with some commercial PCR tests for MRSA detection. We found that an epidemic European CC1-MRSA-IV clone generally exhibits this behaviour. The failure of the assays was attributable to a large insertion in the orfx/SCCmec integration site. To ensure the reliability of molecular MRSA tests, it is vital to monitor emergence of new SCCmec types and junction sites.


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