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Innovations, challenges, and minimal information for standardization of humanized mice

Stripecke, Renata ; Münz, Christian ; Schuringa, Jan Jacob ; Bissig, Karl‐Dimiter ; Soper, Brian ; Meeham, Terrence ; Yao, Li‐Chin ; Di Santo, James P ; Brehm, Michael ; Rodriguez, Estefania ; Wege, Anja Kathrin ; Bonnet, Dominique ; Guionaud, Silvia ; Howard, Kristina E ; Kitchen, Scott ; Klein, Florian ; Saeb‐Parsy, Kourosh ; Sam, Johannes ; Sharma, Amar Deep ; Trumpp, Andreas ; Trusolino, Livio ; Bult, Carol ; Shultz, Leonard



Abstract

Mice xenotransplanted with human cells and/or expressing human gene products (also known as "humanized mice") recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevantin vivocontext for understanding of human-specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are ...

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