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Functional role of endogenous Kv1.4 in experimental demyelination

González-Alvarado, María Nazareth ; Rötger, Caroline ; Berger, Laura ; London, Barry ; Haase, Stefanie ; Kuhbandner, Kristina ; Lee, De-Hyung ; Linker, Ralf A.


During neuroinflammation, the shaker type potassium channel Kv1.4 is re-expressed in oligodendrocytes (Ol), but not immune cells. Here, we analyze the role of endogenous Kv1.4 in two demyelinating animal models of multiple sclerosis. While Kv1.4 deficiency in primary murine Ol led to a decreased proliferation rate in vitro, it did not exert an effect on Ol proliferation or on the extent of de- or ...


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