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PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation

Dozio, Elena ; Ruscica, Massimiliano ; Vianello, Elena ; Macchi, Chiara ; Sitzia, Clementina ; Schmitz, Gerd ; Tacchini, Lorenza ; Corsi Romanelli, Massimiliano M.


Epicardial adipose tissue (EAT) has the unique property to release mediators that nourish the heart in healthy conditions, an effect that becomes detrimental when volume expands and proinflammatory cytokines start to be produced. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a proinflammatory mediator involved in atherosclerosis, is also produced by visceral fat. Due to the correlation ...


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