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Infiltrating immune cells are associated with radiosensitivity and favorable survival in head and neck cancer treated with definitive radiotherapy

Fiedler, Mathias ; Weber, Florian ; Hautmann, Matthias G. ; Bohr, Christopher ; Reichert, Torsten E. ; Ettl, Tobias


Objectives. The aim of this study was to investigate the influence of CD4(+), CD8(+) and Forkhead box protein 3 (FoxP3(+)) tumor-infiltrating lymphocytes, as well as CD1a(+) tumor-infiltrating dendritic cells on the radiosensitivity and survival of primarily chemoirradiated advanced head and neck squamous cell carcinomas. Study Design. Immunohistochemical staining for CD4, CD8, FoxP3 and CD1a was ...


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