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Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study

Bittner, Stefan ; Steffen, Falk ; Uphaus, Timo ; Muthuraman, Muthuraman ; Fleischer, Vinzenz ; Salmen, Anke ; Luessi, Felix ; Berthele, Achim ; Klotz, Luisa ; Meuth, Sven G. ; Bayas, Antonios ; Paul, Friedemann ; Hartung, Hans-Peter ; Linker, Ralf ; Heesen, Christoph ; Stangel, Martin ; Wildemann, Brigitte ; Then Bergh, Florian ; Tackenberg, Björn ; Kuempfel, Tania ; Weber, Frank ; Zettl, Uwe K. ; Ziemann, Ulf ; Tumani, Hayrettin ; Groppa, Sergiu ; Mühlau, Mark ; Lukas, Carsten ; Hemmer, Bernhard ; Wiendl, Heinz ; Gold, Ralf ; Zipp, Frauke



Abstract

Background: We aim to evaluate serum neurofilament light chain (sNfL), indicating neuroaxonal damage, as a biomarker at diagnosis in a large cohort of early multiple sclerosis (MS) patients. Methods: In a multicentre prospective longitudinal observational cohort, patients with newly diagnosed relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) were recruited between August 2010 ...

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