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Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via β2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation

Hedderich, Jessica ; El Bagdadi, Karima ; Angele, Peter ; Grässel, Susanne ; Meurer, Andrea ; Straub, Rainer H. ; Zaucke, Frank ; Jenei-Lanzl, Zsuzsa


Bone marrow-derived mesenchymal stem cells (BMSCs) represent an alternative to chondrocytes to support cartilage regeneration in osteoarthritis (OA). The sympathetic neurotransmitter norepinephrine (NE) has been shown to inhibit their chondrogenic potential; however, their proliferation capacity under NE influence has not been studied yet. Therefore, we used BMSCs obtained from trauma and OA ...


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