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Quantitative Proteomics Identifies TCF1 as a Negative Regulator of Foxp3 Expression in Conventional T Cells

Delacher, Michael ; Barra, Melanie M. ; Herzig, Yonatan ; Eichelbaum, Katrin ; Rafiee, Mahmoud-Reza ; Richards, David M. ; Träger, Ulrike ; Hofer, Ann-Cathrin ; Kazakov, Alexander ; Braband, Kathrin L. ; Gonzalez, Marina ; Wöhrl, Lukas ; Schambeck, Kathrin ; Imbusch, Charles D. ; Abramson, Jakub ; Krijgsveld, Jeroen ; Feuerer, Markus



Abstract

Regulatory T cells are important regulators of the immune system and have versatile functions for the homeostasis and repair of tissues. They express the forkhead box transcription factor Foxp3 as a lineage-defining protein. Negative regulators of Foxp3 expression are not well understood. Here, we generated double-stranded DNA probes complementary to the Foxp3 promoter sequence and performed a ...

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