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Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

Zheng, Yan ; Huang, Tao ; Wang, Tiange ; Mei, Zhendong ; Sun, Zhonghan ; Zhang, Tao ; Ellervik, Christina ; Chai, Jin-Fang ; Sim, Xueling ; van Dam, Rob M. ; Tai, E-Shyong ; Koh, Woon-Puay ; Dorajoo, Rajkumar ; Saw, Seang-Mei ; Sabanayagam, Charumathi ; Wong, Tien Yin ; Gupta, Preeti ; Rossing, Peter ; Ahluwalia, Tarunveer S. ; Vinding, Rebecca K. ; Bisgaard, Hans ; Bønnelykke, Klaus ; Wang, Yujie ; Graff, Mariaelisa ; Voortman, Trudy ; van Rooij, Frank J. A. ; Hofman, Albert ; van Heemst, Diana ; Noordam, Raymond ; Estampador, Angela C. ; Varga, Tibor V. ; Enzenbach, Cornelia ; Scholz, Markus ; Thiery, Joachim ; Burkhardt, Ralph ; Orho-Melander, Marju ; Schulz, Christina-Alexandra ; Ericson, Ulrika ; Sonestedt, Emily ; Kubo, Michiaki ; Akiyama, Masato ; Zhou, Ang ; Kilpeläinen, Tuomas O. ; Hansen, Torben ; Kleber, Marcus E. ; Delgado, Graciela ; McCarthy, Mark ; Lemaitre, Rozenn N. ; Felix, Janine F. ; Jaddoe, Vincent W. V. ; Wu, Ying ; Mohlke, Karen L. ; Lehtimäki, Terho ; Wang, Carol A. ; Pennell, Craig E. ; Schunkert, Heribert ; Kessler, Thorsten ; Zeng, Lingyao ; Willenborg, Christina ; Peters, Annette ; Lieb, Wolfgang ; Grote, Veit ; Rzehak, Peter ; Koletzko, Berthold ; Erdmann, Jeanette ; Munz, Matthias ; Wu, Tangchun ; He, Meian ; Yu, Caizheng ; Lecoeur, Cécile ; Froguel, Philippe ; Corella, Dolores ; Moreno, Luis A. ; Lai, Chao-Qiang ; Pitkänen, Niina ; Boreham, Colin A. ; Ridker, Paul M. ; Rosendaal, Frits R. ; de Mutsert, Renée ; Power, Chris ; Paternoster, Lavinia ; Sørensen, Thorkild I. A. ; Tjønneland, Anne ; Overvad, Kim ; Djousse, Luc ; Rivadeneira, Fernando ; Lee, Nanette R. ; Raitakari, Olli T. ; Kähönen, Mika ; Viikari, Jorma ; Langhendries, Jean-Paul ; Escribano, Joaquin ; Verduci, Elvira ; Dedoussis, George ; König, Inke ; Balkau, Beverley ; Coltell, Oscar ; Dallongeville, Jean ; Meirhaeghe, Aline ; Amouyel, Philippe ; Gottrand, Frédéric ; Pahkala, Katja ; Niinikoski, Harri ; Hyppönen, Elina ; März, Winfried ; Mackey, David A. ; Gruszfeld, Dariusz ; Tucker, Katherine L. ; Fumeron, Frédéric ; Estruch, Ramon ; Ordovas, Jose M. ; Arnett, Donna K. ; Mook-Kanamori, Dennis O. ; Mozaffarian, Dariush ; Psaty, Bruce M. ; North, Kari E. ; Chasman, Daniel I. ; Qi, Lu



Abstract

Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data of 183,433 participants from 60 studies (CHARGE-BIG ...

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